Q&A: Why are a child’s first 1,000 days so critical for brain building?

Year after year, government records show late summer is when most babies are born, with August as the most common birth month. That means – right now – tens of thousands of future parents are planning nursery colors, work leave and childbirth classes.

According to the University of Virginia’s Meghan Puglia, an associate professor of neurology and a researcher in the School of Medicine, it’s also important for expectant parents to plan for the child’s first 1,000 days.

That period from birth to the doorstep of a third birthday is unmatched for the potential of explosive brain development, said Puglia, who made that point recently in a .

Puglia, a mother of two, recently chatted with UVA Today about what’s happening in baby brains during that time, and how parents can maximize a child’s potential.

Portrait of Meghan Puglia in the School of Medicine

Puglia, an associate professor of neurology in the School of Medicine, says every interaction with a baby shapes the development of a brain that “builds itself at a breathtaking pace” in the first 1,000 days. (Photo by Lathan Goumas, University Communications)

Q. You talk about the importance of a baby’s first 1,000 days. What’s going on during that time that is so foundational?

A. During the first 1,000 days, the brain builds itself at a breathtaking pace, forming up to a million neural connections per second, while the genes that shape who we will become begin tuning themselves. But these processes aren’t automatic. Every experience strengthens some brain connections, lets others fade and turns certain genes up or down. Even before birth, stress, nutrition and maternal care shape neural circuits and gene expression. After birth, every cuddle, coo and smile continues to sculpt the brain and fine-tune genes, setting up baby for a lifetime of learning, behavior and health.

Q. You also emphasize parents should “turn down the stress” when attending to a baby, but caring for a baby can be incredibly stressful. How should parents balance those two things?

A. It’s not about being calm all the time – that’s impossible and striving for it only adds stress.

What matters is keeping stress from becoming constant or overwhelming.

Biology works best in the middle: not chaos, not perfection. If you’re exhausted or overwhelmed, step away safely, ask for help, take a breath. Caring for yourself isn’t indulgent; it directly shapes your baby’s biology.

During pregnancy, mom’s stress hormones can directly impact the developing baby. But even after birth, a regulated parent is the strongest stress buffer a young child has. Responsive, attuned care can even counterbalance stressful moments. For example, if a baby is struggling with separation at day care, extra attention and warmth when you are together can help regulate their stress response.

Q. How has your work as a baby-brain expert changed the way you parent your two children?

A. Knowing the science doesn’t make parenting easy. I still miss cues, get tired and lose patience. What my research reminds me is that resilience, creativity and competence aren’t built from flawless parenting.

Developing brains need variability and mild challenges, so I remind myself it’s OK if my kids struggle a bit and figure things out themselves. I try to focus on intention, not perfection: showing up, repairing after hard moments and modeling emotional resilience after imperfection. And trust me, I have plenty of imperfect moments.

Q. New parents are seeing AI-powered baby care options, like automated feeders, smart rockers and tech-laden baby monitors. What role should AI play in newborn care?

A. AI can be incredibly helpful, especially when it reduces parental stress or catches medical concerns early. I’m not anti-technology, but I am anti-replacement.

The earliest interactions between babies and their primary caregivers are the most critical for building trust, resilience and the foundation for social and emotional skills. Babies and parents learn through trial and error – noticing each other’s cues, responding, adjusting and discovering how to reliably meet each other’s needs. AI can support parents, but it can’t replace these imperfect, responsive human interactions that actually build strong brains and secure attachment.

Meghan Puglia and her baby girl wearing medical caps

Puglia holds her daughter while they both wear caps that measure brain activity. Even though she studies best practices for interacting with babies, she admits she doesn’t always get it right, but that’s OK. “Your baby doesn’t need a perfectly scheduled, perfectly stimulated life – they need you,” she says. (Contributed photo)

Q. Let’s say a baby, for a variety of circumstances, didn’t get an ideal start in his or her first three years. Can they still catch up?

A. Absolutely. Early development is powerful, but it’s not destiny. The brain remains plastic even into adulthood. I never want parents to hear “first 1,000 days” and think the door slams shut. Sensitive periods during development make learning easier, but even beyond them, the brain can adapt with intention. Enriched experiences, supportive relationships and consistent effort can help a child regain ground.

Progress may take more work, but with targeted, responsive inputs, the brain can adapt in ways that are remarkable.

Q. Already, parents – especially first-time parents – feel they’re under enormous pressure. What’s your best advice?

A. Focus on showing up, not on getting it “right.” Your baby doesn’t need a perfectly scheduled, perfectly stimulated life – they need you. Pay attention to their cues, respond with presence and allow yourself to make mistakes. Small, everyday interactions – a touch, a shared laugh, eye contact – shape the brain more than anything else. Love, intention and repair matter far more than perfection.

Media Contacts

Mike Mather

Executive Editor University Communications