WEBVTT Kind: captions Language: en 00:00:00.740 --> 00:00:05.630 We think we know everything, but we don't know most things. 00:00:05.630 --> 00:00:10.339 We've been looking into the area which was believed to be, immunologically, a very active area of the brain. 00:00:10.339 --> 00:00:15.289 How do immune cells get into the brain and how do they get out of the brain? 00:00:15.289 --> 00:00:19.920 And, so what Antoine did is say, O.K. if we see these major changes in the meninges why don't 00:00:19.920 --> 00:00:23.000 we just look at the meninges, but not, you know, piece-by-piece. 00:00:23.000 --> 00:00:25.000 Let's take the whole thing and put it on a slide. 00:00:26.000 --> 00:00:31.000 And, then here it was. We found these beautiful lymphatic vessels going along the sinuses. 00:00:32.000 --> 00:00:34.840 You know how sometimes you see it and you know that this is something very, very, very, cool? 00:00:36.500 --> 00:00:40.470 Most neurological disorders have an immune component: Autism, 00:00:40.470 --> 00:00:42.500 Parkinson's, Alzheimer's, Glaucoma. 00:00:43.000 --> 00:00:47.000 So what we are suggesting is, if the immune system has such a prominent effect on the brain, 00:00:47.000 --> 00:00:50.940 Can we harness this immune system and maybe target it? 00:00:51.200 --> 00:00:55.000 Because it's so easily accessible, so is it druggable? Even replaceable! 00:00:55.420 --> 00:00:59.240 Can we maybe target the immune system for the benefit of the brain? That's what we are going after. 00:01:00.000 --> 00:01:03.450 University of Virginia is now being recognized for its strength in 00:01:03.450 --> 00:01:08.000 Neuroimmunology. So in five years when everybody will want to be in Neuroimmunology, 00:01:08.000 --> 00:01:10.000 UVA will be the place! 00:01:10.000 --> 00:01:15.000 I believe that to do good science, you need one thing, a passion. 00:01:15.180 --> 00:01:17.500 So if you're excited about your question you'll find something interesting, 00:01:17.500 --> 00:01:19.000 because we don't know most things. 00:01:19.140 --> 00:01:20.540 But if you are passionate about it, 00:01:20.540 --> 00:01:22.340 it will lead you somewhere!