WEBVTT Kind: captions Language: en 00:00:08.091 --> 00:00:09.300 Good afternoon, everyone. 00:00:09.300 --> 00:00:10.343 My name is Jim Ryan. 00:00:10.343 --> 00:00:13.847 And I am the president of the University of Virginia. 00:00:13.847 --> 00:00:17.600 I am delighted to see and welcome all of you 00:00:17.600 --> 00:00:20.520 to this truly special and exciting day. 00:00:20.520 --> 00:00:24.315 Speaking personally, the last time I was this excited 00:00:24.315 --> 00:00:26.484 was earlier this week when I had a chance 00:00:26.484 --> 00:00:30.196 to meet Steph Curry at a UVA basketball game, which 00:00:30.196 --> 00:00:32.532 means I'm very, very excited. 00:00:32.532 --> 00:00:34.909 I'd like to extend a special welcome to Governor Glenn 00:00:34.909 --> 00:00:38.121 Youngkin and first lady Suzanne Youngkin. 00:00:38.121 --> 00:00:41.750 We are here today to make the formal announcement of what 00:00:41.750 --> 00:00:46.254 I see as a landmark, not only in the history of this University, 00:00:46.254 --> 00:00:49.507 but also in the history of medical research and treatment 00:00:49.507 --> 00:00:51.843 in the Commonwealth and beyond. 00:00:51.843 --> 00:00:53.428 I realize that what I'm about to say 00:00:53.428 --> 00:00:55.847 may seem like a slight exaggeration. 00:00:55.847 --> 00:00:59.017 And I say this admittedly as an American Studies 00:00:59.017 --> 00:01:01.603 major in college and a lawyer by training who 00:01:01.603 --> 00:01:03.938 has no expertise in medicine. 00:01:03.938 --> 00:01:08.485 But I believe that we are at the dawn of a revolution 00:01:08.485 --> 00:01:09.861 in medical treatment. 00:01:09.861 --> 00:01:13.698 Today, there are more than 9,500 diseases without a cure, 00:01:13.698 --> 00:01:16.826 and 1 in 10 Virginians suffers from a rare disease 00:01:16.826 --> 00:01:17.994 without a cure. 00:01:17.994 --> 00:01:21.331 In the past, these diseases, which range 00:01:21.331 --> 00:01:24.709 from various types of cancer to Alzheimer's to sickle 00:01:24.709 --> 00:01:27.670 cell disease, have seemed intractable. 00:01:27.670 --> 00:01:31.758 But advances in biotechnology, and in particular, gene 00:01:31.758 --> 00:01:34.594 and cellular therapy as well as immunotherapy, 00:01:34.594 --> 00:01:37.639 have given great cause for hope because they represent 00:01:37.639 --> 00:01:40.683 a new and incredibly promising way 00:01:40.683 --> 00:01:42.644 of attacking these diseases. 00:01:42.644 --> 00:01:46.231 If I'm right, the next quarter century or so 00:01:46.231 --> 00:01:48.525 will be the age of biotechnology. 00:01:48.525 --> 00:01:52.737 And we will see advances that rival or exceed the advances 00:01:52.737 --> 00:01:56.491 in information technology that we've seen in the last quarter 00:01:56.491 --> 00:01:57.534 century. 00:01:57.534 --> 00:02:00.328 That is why it is my pleasure and honor 00:02:00.328 --> 00:02:03.957 to announce the creation of the Paul and Diane Manning 00:02:03.957 --> 00:02:07.585 Biotechnology Institute at the University of Virginia. 00:02:07.585 --> 00:02:10.630 This Institute will be an innovative translational 00:02:10.630 --> 00:02:14.509 research center that will bring new medical treatments to those 00:02:14.509 --> 00:02:15.844 who need them most. 00:02:15.844 --> 00:02:18.721 This Institute, as you might have guessed from the name, 00:02:18.721 --> 00:02:24.477 is made possible by a stunningly generous gift of $100 million 00:02:24.477 --> 00:02:27.021 from Paul and Diane Manning. 00:02:27.021 --> 00:02:30.441 [APPLAUSE] 00:02:56.593 --> 00:02:58.428 The Manning gift will be combined 00:02:58.428 --> 00:03:00.889 with an historic investment from the Commonwealth, 00:03:00.889 --> 00:03:03.391 thanks to the strong support of Governor Youngkin, 00:03:03.391 --> 00:03:05.768 and key members of the General Assembly. 00:03:05.768 --> 00:03:09.480 The University is also contributing $150 million 00:03:09.480 --> 00:03:13.234 to this effort, in alignment with our 2030 strategic plan 00:03:13.234 --> 00:03:16.779 which calls for a focus on precision medicine. 00:03:16.779 --> 00:03:20.158 It is difficult to overstate the importance of this Institute 00:03:20.158 --> 00:03:22.535 to UVA and to the Commonwealth. 00:03:22.535 --> 00:03:25.622 The Manning Institute will be the hub of UVA's research 00:03:25.622 --> 00:03:27.332 program in biotechnology. 00:03:27.332 --> 00:03:29.792 It will include a state-of-the-art building 00:03:29.792 --> 00:03:32.921 centered on the research, development, commercialisation, 00:03:32.921 --> 00:03:35.673 and manufacturing of new cellular gene 00:03:35.673 --> 00:03:36.966 and immunotherapies. 00:03:36.966 --> 00:03:39.719 It will bring together researchers and scientists 00:03:39.719 --> 00:03:42.597 from biomedical, engineering, and chemical sciences 00:03:42.597 --> 00:03:43.806 at the University. 00:03:43.806 --> 00:03:45.767 And it will create new opportunities 00:03:45.767 --> 00:03:48.770 for students and faculty to be at the forefront 00:03:48.770 --> 00:03:50.021 of medical science. 00:03:50.021 --> 00:03:53.566 It will foster an environment that inspires, supports, 00:03:53.566 --> 00:03:56.861 accelerates, and promotes discoveries and innovation, 00:03:56.861 --> 00:04:00.573 even for health care challenges that have, until now, seemed 00:04:00.573 --> 00:04:01.699 insurmountable. 00:04:01.699 --> 00:04:04.786 And it will supply the infrastructure and resources 00:04:04.786 --> 00:04:07.205 that are needed to bring discoveries 00:04:07.205 --> 00:04:10.708 from the bench to the bedside as quickly as we can. 00:04:10.708 --> 00:04:14.796 The Manning Institute will also play an important economic role 00:04:14.796 --> 00:04:16.297 for the broader community. 00:04:16.297 --> 00:04:19.717 If we do this right, and we will work tirelessly 00:04:19.717 --> 00:04:22.053 to do this right, the institute will 00:04:22.053 --> 00:04:25.640 attract both startups and established biotech firms 00:04:25.640 --> 00:04:28.059 and help accelerate the growth of UVA 00:04:28.059 --> 00:04:31.562 and the city of Charlottesville as a formidable hub 00:04:31.562 --> 00:04:32.814 of innovation. 00:04:32.814 --> 00:04:35.441 Our plans go even further than this, however, 00:04:35.441 --> 00:04:39.153 as we expect the Institute's reach will extend to citizens 00:04:39.153 --> 00:04:41.948 across the Commonwealth through participation 00:04:41.948 --> 00:04:44.325 in clinical trials throughout Virginia 00:04:44.325 --> 00:04:46.494 and through the manufacturing facility, which 00:04:46.494 --> 00:04:48.538 will be a part of the institute, and which 00:04:48.538 --> 00:04:52.041 will be available to researchers from our sister institutions 00:04:52.041 --> 00:04:53.835 across the Commonwealth. 00:04:53.835 --> 00:04:57.672 This is not, in other words, about UVA per se 00:04:57.672 --> 00:04:59.382 nor is it about an Institute that 00:04:59.382 --> 00:05:01.134 might just help the university. 00:05:01.134 --> 00:05:04.178 This is about creating an avenue by which UVA 00:05:04.178 --> 00:05:08.558 can help improve and save lives throughout the Commonwealth. 00:05:08.558 --> 00:05:11.311 None of this would be possible without 00:05:11.311 --> 00:05:14.689 the visionary generosity of Paul and Diane Manning. 00:05:14.689 --> 00:05:16.733 For those of you who don't know him, 00:05:16.733 --> 00:05:20.153 Paul is an incredibly successful entrepreneur and the founder 00:05:20.153 --> 00:05:24.157 of the PBM Capital Group, which is based in Charlottesville. 00:05:24.157 --> 00:05:26.909 Paul and Diane have been heavily involved 00:05:26.909 --> 00:05:28.536 with philanthropy and health care 00:05:28.536 --> 00:05:30.121 through their Family Foundation. 00:05:30.121 --> 00:05:33.541 And Paul has served on UVA's Health Foundation Board, 00:05:33.541 --> 00:05:36.210 as well as on the Steering Committee for the University's 00:05:36.210 --> 00:05:39.464 Strategic Planning Process back in 2013. 00:05:39.464 --> 00:05:42.383 Diane has been involved with a number of boards 00:05:42.383 --> 00:05:44.469 and organizations, including serving 00:05:44.469 --> 00:05:47.555 as director of the Manning Family Foundation 00:05:47.555 --> 00:05:51.517 and co-founder of Focus to Cure Diabetes Foundation. 00:05:51.517 --> 00:05:55.521 In 2010, she received the inaugural Richmond Dining 00:05:55.521 --> 00:05:58.149 in the Dark Visionary Award for her dedication 00:05:58.149 --> 00:05:59.525 to fighting blindness. 00:05:59.525 --> 00:06:02.737 Paul and Diane have already given generously 00:06:02.737 --> 00:06:06.532 to health research at UVA, as well as to UVA athletics. 00:06:06.532 --> 00:06:10.078 They have three children, who are all UVA graduates. 00:06:10.078 --> 00:06:13.081 My wife Katie and I have had the good fortune 00:06:13.081 --> 00:06:15.124 to get to know Paul and Diane. 00:06:15.124 --> 00:06:17.668 And I can tell you there are few people who 00:06:17.668 --> 00:06:20.963 rival their combination of commitment, generosity, 00:06:20.963 --> 00:06:22.965 goodwill, and good humor. 00:06:22.965 --> 00:06:27.387 Paul and Diane, I am incredibly grateful to call you friends. 00:06:27.387 --> 00:06:30.890 And I'm both grateful and in awe of your relentless commitment 00:06:30.890 --> 00:06:34.060 to serving patients and their families. 00:06:34.060 --> 00:06:36.729 I'd also like to thank Governor Youngkin, whom we will 00:06:36.729 --> 00:06:38.314 hear from in a few moments. 00:06:38.314 --> 00:06:40.900 He has been a champion of scientific advances 00:06:40.900 --> 00:06:41.651 in health care. 00:06:41.651 --> 00:06:44.404 And I'm grateful for his partnership and his confidence 00:06:44.404 --> 00:06:46.322 in the University of Virginia. 00:06:46.322 --> 00:06:49.200 In addition, it has been a genuine pleasure 00:06:49.200 --> 00:06:51.828 to work with many elected and appointed officials 00:06:51.828 --> 00:06:54.038 from the Commonwealth on this initiative, 00:06:54.038 --> 00:06:57.458 including Speaker Todd Gilbert, who is with us today. 00:06:57.458 --> 00:07:01.421 For those in Richmond who have helped us along the way, 00:07:01.421 --> 00:07:04.132 let me just say that we share your excitement 00:07:04.132 --> 00:07:07.635 and your commitment to ensure that this investment pays off 00:07:07.635 --> 00:07:09.679 for all Virginians. 00:07:09.679 --> 00:07:12.890 Thanks as well to Dr. Craig Kent, CEO of UVA Health, 00:07:12.890 --> 00:07:16.727 for lending his leadership and expertise to the development 00:07:16.727 --> 00:07:17.770 of the Manning Institute. 00:07:17.770 --> 00:07:20.106 Craig and his team have been instrumental 00:07:20.106 --> 00:07:22.150 in the design and the planning of this effort. 00:07:22.150 --> 00:07:25.862 And his wise counsel has been incredibly valuable throughout. 00:07:25.862 --> 00:07:28.531 Finally I'd like to thank UVA's provost Ian 00:07:28.531 --> 00:07:32.493 Baucom for his wisdom and advice on incorporating the Manning 00:07:32.493 --> 00:07:36.122 Institute into the academic mission of the University. 00:07:36.122 --> 00:07:40.168 Ian and his team have provided, and will continue to provide, 00:07:40.168 --> 00:07:43.171 outstanding academic leadership as the institute 00:07:43.171 --> 00:07:47.133 grows from an idea into reality. 00:07:47.133 --> 00:07:50.303 Before I turn it over to the Rector of the University 00:07:50.303 --> 00:07:53.848 Whitt Clement, let me say a final word about the promise 00:07:53.848 --> 00:07:56.058 of the Manning Institute. 00:07:56.058 --> 00:07:58.686 We often say that UVA is a place that 00:07:58.686 --> 00:08:02.315 strives to be both great and good in all that we do. 00:08:02.315 --> 00:08:05.193 When people ask me, what does that mean? 00:08:05.193 --> 00:08:08.529 I usually cite a few examples to help explain. 00:08:08.529 --> 00:08:09.989 So, too, here. 00:08:09.989 --> 00:08:12.033 The Manning Institute will bring together 00:08:12.033 --> 00:08:15.328 world class researchers in biotechnology 00:08:15.328 --> 00:08:18.498 who will help bring life-changing and life-saving 00:08:18.498 --> 00:08:21.792 treatments to those who need them the most. 00:08:21.792 --> 00:08:25.213 That is what great and good looks like. 00:08:25.213 --> 00:08:28.132 Thanks again to all of you for being here. 00:08:28.132 --> 00:08:31.928 And with that, I'd like to ask my friend and my boss Rector 00:08:31.928 --> 00:08:33.804 Clement to come to the podium. 00:08:33.804 --> 00:08:34.388 Thank you. 00:08:34.388 --> 00:08:37.850 [APPLAUSE] 00:08:43.773 --> 00:08:46.651 Thank you, President Ryan. 00:08:46.651 --> 00:08:52.740 Paul, Diane, on behalf of all the members 00:08:52.740 --> 00:08:55.326 of the Board of Visitors, we are most 00:08:55.326 --> 00:09:00.414 grateful for this incredibly wonderful gift that's 00:09:00.414 --> 00:09:05.086 going to fund an institute, whose research and discovery 00:09:05.086 --> 00:09:08.839 is going to mean so much to so many people 00:09:08.839 --> 00:09:14.845 in our Commonwealth, in our nation, and worldwide. 00:09:14.845 --> 00:09:18.057 We are proud and deeply honored that you've 00:09:18.057 --> 00:09:23.479 entrusted us through your philanthropy 00:09:23.479 --> 00:09:27.024 for cutting-edge research. 00:09:27.024 --> 00:09:29.986 It's a real historic day at the university. 00:09:29.986 --> 00:09:34.407 And we really can't thank you enough. 00:09:34.407 --> 00:09:39.495 My main duty, other than to express our deep appreciation, 00:09:39.495 --> 00:09:42.748 is to introduce two very special guests. 00:09:42.748 --> 00:09:45.126 And the president has already mentioned. 00:09:45.126 --> 00:09:49.547 Each is going to offer his own comments. 00:09:49.547 --> 00:09:50.965 The Speaker of the Virginia House 00:09:50.965 --> 00:09:54.927 of Delegates, and of course, our governor. 00:09:54.927 --> 00:09:58.389 First, Speaker Todd Gilbert. 00:09:58.389 --> 00:10:03.519 Todd is one of our own, a graduate of the college where 00:10:03.519 --> 00:10:06.022 he earned his degree in 1993. 00:10:06.022 --> 00:10:11.569 He went on to gain his law degree from SMU. 00:10:11.569 --> 00:10:17.658 Todd's service in the house for the last almost 17 years 00:10:17.658 --> 00:10:22.413 really epitomizes Virginia's long history 00:10:22.413 --> 00:10:26.500 of producing public servants who serve in leadership 00:10:26.500 --> 00:10:29.295 roles in state government. 00:10:29.295 --> 00:10:33.674 Todd is a major figure, along with the Governor, 00:10:33.674 --> 00:10:37.845 of course, in how our state operates. 00:10:37.845 --> 00:10:42.850 Todd and his wife, Jennifer, have two small children. 00:10:42.850 --> 00:10:47.146 They live in Woodstock in the Shenandoah Valley. 00:10:47.146 --> 00:10:49.315 We're also honored, of course, to have 00:10:49.315 --> 00:10:53.611 with us Governor Glenn Youngkin, who, as president Ryan 00:10:53.611 --> 00:10:58.115 has mentioned, has been a stalwart supporter of advancing 00:10:58.115 --> 00:11:01.744 healthcare research and technology initiatives 00:11:01.744 --> 00:11:03.412 in the Commonwealth. 00:11:03.412 --> 00:11:06.040 He, along with many of our friends in the General 00:11:06.040 --> 00:11:09.377 Sunday like Speaker Gilbert, have 00:11:09.377 --> 00:11:15.007 been instrumental in making this important institute a reality. 00:11:15.007 --> 00:11:16.592 As many of know, Governor Youngkin 00:11:16.592 --> 00:11:20.721 is a native of Virginia Beach. 00:11:20.721 --> 00:11:22.390 He obtained his engineering degree 00:11:22.390 --> 00:11:27.812 from Rice University, and his MBA from Harvard. 00:11:27.812 --> 00:11:32.692 Before his successful run for governor in 2021, 00:11:32.692 --> 00:11:34.944 he had been with the Carlyle Group, 00:11:34.944 --> 00:11:38.989 an international investment firm, for 25 years 00:11:38.989 --> 00:11:44.704 and eventually rose to the position of co-CEO. 00:11:44.704 --> 00:11:47.873 He and our first lady Suzanne, who we're also 00:11:47.873 --> 00:11:50.918 very happy that you're with us today, 00:11:50.918 --> 00:11:54.588 have been married for 28 years, have four children. 00:11:54.588 --> 00:11:57.925 And one of them is doing research at the hospital. 00:11:57.925 --> 00:12:00.970 So thank you also for being here. 00:12:00.970 --> 00:12:03.180 Governor the university looks forward 00:12:03.180 --> 00:12:06.517 to building this partnership with the Commonwealth, 00:12:06.517 --> 00:12:08.978 as President Ryan has mentioned. 00:12:08.978 --> 00:12:12.648 We want that partnership so that the Manning Institute 00:12:12.648 --> 00:12:15.651 can reach its full potential. 00:12:15.651 --> 00:12:20.865 We hope that this institute and its groundbreaking work 00:12:20.865 --> 00:12:25.244 will be as much a part of your legacy 00:12:25.244 --> 00:12:28.247 as it will be the Manning family. 00:12:28.247 --> 00:12:29.915 So thank you again. 00:12:29.915 --> 00:12:34.253 And I'd now like to recognize my friend, Todd Gilbert. 00:12:34.253 --> 00:12:37.673 [APPLAUSE] 00:12:42.052 --> 00:12:42.553 Thank you. 00:12:42.553 --> 00:12:46.307 Well, Governor Youngkin, President Ryan, 00:12:46.307 --> 00:12:49.935 Rector Clements, Mr. and Mrs. Manning, honored guests, 00:12:49.935 --> 00:12:51.771 it is a delight to be with you today. 00:12:51.771 --> 00:12:55.649 I had my staff, as staffs do, said, here 00:12:55.649 --> 00:12:56.984 are your remarks for today. 00:12:56.984 --> 00:12:59.904 And I said, well, I think I'd rather tell a story because I 00:12:59.904 --> 00:13:02.656 have a story to tell here. 00:13:02.656 --> 00:13:05.326 It started with a phone call, a phone 00:13:05.326 --> 00:13:10.539 call from my closest friend and confidant and on and off again 00:13:10.539 --> 00:13:11.207 roommate. 00:13:11.207 --> 00:13:13.501 We have to save money when we're in Richmond 00:13:13.501 --> 00:13:14.710 in the House of Delegates. 00:13:14.710 --> 00:13:16.629 And that would be one Rob Bell. 00:13:16.629 --> 00:13:20.299 Many of Rob is the representative from just 00:13:20.299 --> 00:13:24.261 over the artificial border in Albemarle County. 00:13:24.261 --> 00:13:28.015 Rob is what they call a Double Hoo. 00:13:28.015 --> 00:13:29.183 I am not one of those. 00:13:29.183 --> 00:13:32.561 And when people ask, I told them I went to school here. 00:13:32.561 --> 00:13:35.397 And they say, well, did you go to law school also? 00:13:35.397 --> 00:13:38.734 My response is always, no, they didn't want me back, 00:13:38.734 --> 00:13:40.277 which is just my fault really. 00:13:40.277 --> 00:13:45.074 It's not your fault. It's no one's fault. It's my fault. 00:13:45.074 --> 00:13:47.493 But Rob Bell worked very hard when he was in school here. 00:13:47.493 --> 00:13:49.995 And so he has the honor of being a Double Hoo. 00:13:49.995 --> 00:13:50.955 And I got that call. 00:13:50.955 --> 00:13:53.290 And it's not unusual for me to get a call from Rob Bell. 00:13:53.290 --> 00:13:55.084 I get five calls a day from Rob Bell, 00:13:55.084 --> 00:13:57.294 and have for years because he's always 00:13:57.294 --> 00:13:58.337 thinking about something. 00:13:58.337 --> 00:13:59.296 Trying to fix something. 00:13:59.296 --> 00:14:00.506 Trying to navigate something. 00:14:00.506 --> 00:14:02.591 He really is the hardest working member 00:14:02.591 --> 00:14:04.510 of the House of Delegates. 00:14:04.510 --> 00:14:08.889 And Rob called and said that he had a friend and constituent 00:14:08.889 --> 00:14:12.476 who I needed to meet with, who was thinking 00:14:12.476 --> 00:14:16.272 of making a historic investment in the University 00:14:16.272 --> 00:14:18.983 and in the Commonwealth of Virginia. 00:14:18.983 --> 00:14:23.654 And so I gladly agreed to come and meet 00:14:23.654 --> 00:14:26.323 with Mr. Manning at his lovely home. 00:14:26.323 --> 00:14:27.575 I drove out there. 00:14:27.575 --> 00:14:28.701 Rob was there. 00:14:28.701 --> 00:14:30.703 And we just sat down and talked. 00:14:30.703 --> 00:14:35.207 And for about an hour, I got to hear Mr. Manning's vision 00:14:35.207 --> 00:14:38.419 of what health care was going to look like 10 years from now. 00:14:38.419 --> 00:14:40.629 And I was hooked, and I was sold. 00:14:40.629 --> 00:14:44.884 And it was my understanding then that not only was he 00:14:44.884 --> 00:14:47.136 prepared to step up and make this historic investment, 00:14:47.136 --> 00:14:48.971 the University was prepared to do that. 00:14:48.971 --> 00:14:52.975 And they needed a partner, an equal partner, in the state, 00:14:52.975 --> 00:14:54.768 in the Commonwealth of Virginia, to step up 00:14:54.768 --> 00:14:58.898 and embrace this concept and help bring it to fruition. 00:14:58.898 --> 00:15:01.025 Now, at any point, when it sounds 00:15:01.025 --> 00:15:04.904 like I'm boasting about our participation in this thing, 00:15:04.904 --> 00:15:07.156 those of us in government, it's easier 00:15:07.156 --> 00:15:09.033 to spend other people's $100 million 00:15:09.033 --> 00:15:11.243 than it is to spend your own $100 million. 00:15:11.243 --> 00:15:14.288 So I am not equating any of this in any way 00:15:14.288 --> 00:15:17.666 with your personal sacrifice of your treasure. 00:15:17.666 --> 00:15:20.544 And it is an incredible thing. 00:15:20.544 --> 00:15:23.088 But for this to happen, certain things needed to happen. 00:15:23.088 --> 00:15:26.342 So we hatched a plan. 00:15:26.342 --> 00:15:29.678 We were just coming back into the majority in Richmond, 00:15:29.678 --> 00:15:31.639 the Republican caucus. 00:15:31.639 --> 00:15:37.311 And we needed to have our incoming money people invested 00:15:37.311 --> 00:15:38.520 in this literally. 00:15:38.520 --> 00:15:44.360 Figuratively, they needed to buy in to this idea. 00:15:44.360 --> 00:15:47.488 And so we hatched a plan to all go together and meet 00:15:47.488 --> 00:15:51.283 with the incoming chairman of appropriations in Norfolk. 00:15:51.283 --> 00:15:54.828 And we all sat down together at the University, Mr. Manning, 00:15:54.828 --> 00:16:00.167 Rob, me, and the chairman of appropriations, Barry Knight, 00:16:00.167 --> 00:16:03.545 and talk through the same thing. 00:16:03.545 --> 00:16:07.549 And it was really incredible how Chairman Knight bought in. 00:16:07.549 --> 00:16:09.468 And I remember having a conversation with him, 00:16:09.468 --> 00:16:10.844 telling him how important this was 00:16:10.844 --> 00:16:15.808 to me, as a product of this University and as a citizen 00:16:15.808 --> 00:16:16.558 this Commonwealth. 00:16:16.558 --> 00:16:19.186 And I said, Barry, at some point, 00:16:19.186 --> 00:16:22.398 this concept, what's going to be built here, 00:16:22.398 --> 00:16:24.984 is going to save your life, or it's going to save mine, 00:16:24.984 --> 00:16:27.361 or it's going to save somebody you care about or somebody 00:16:27.361 --> 00:16:28.612 I care about. 00:16:28.612 --> 00:16:31.532 And just extrapolate that out across the thousands of people 00:16:31.532 --> 00:16:35.202 that are going to be affected by this new frontier in medicine. 00:16:35.202 --> 00:16:39.164 And whether it's from our families, or yours, 00:16:39.164 --> 00:16:41.667 or the Commonwealth, or the United States, 00:16:41.667 --> 00:16:43.085 or really across the world, people 00:16:43.085 --> 00:16:45.629 are going to come here for the treatments that 00:16:45.629 --> 00:16:48.841 are going to be developed here and applied here 00:16:48.841 --> 00:16:52.094 in this fascinating new world of medicine 00:16:52.094 --> 00:16:53.595 that we're looking at right now. 00:16:53.595 --> 00:16:56.932 And I couldn't be happier to have 00:16:56.932 --> 00:17:00.519 played a small part in bringing this all to fruition. 00:17:00.519 --> 00:17:02.771 And I think it was fortuitous that two 00:17:02.771 --> 00:17:05.899 sons of this University just happened 00:17:05.899 --> 00:17:08.736 to be at a place and a time that we 00:17:08.736 --> 00:17:10.821 could help make this a reality. 00:17:10.821 --> 00:17:15.034 And so for our part, we are delighted to be involved 00:17:15.034 --> 00:17:16.201 and to be partners with you. 00:17:16.201 --> 00:17:18.912 And for my part, if I have anything to do with it, 00:17:18.912 --> 00:17:21.165 if I have any longevity in Richmond, 00:17:21.165 --> 00:17:22.291 we're just getting started. 00:17:22.291 --> 00:17:25.502 So I thank you for this opportunity, 00:17:25.502 --> 00:17:26.587 Mr. Manning, Mrs. Manning. 00:17:26.587 --> 00:17:30.966 I appreciate your historic investment and your vision. 00:17:30.966 --> 00:17:32.801 And thank you so much. 00:17:32.801 --> 00:17:33.343 Yes, sir. 00:17:33.343 --> 00:17:36.805 [APPLAUSE] 00:17:40.309 --> 00:17:41.810 So I almost forgot. 00:17:41.810 --> 00:17:45.397 It became late in the game, I realized my duty 00:17:45.397 --> 00:17:46.774 to do the honors here today. 00:17:46.774 --> 00:17:50.652 And it is truly my honor to introduce His Excellency, 00:17:50.652 --> 00:17:52.279 the governor of Virginia. 00:17:52.279 --> 00:17:55.365 He's likewise, a fantastic partner. 00:17:55.365 --> 00:17:58.786 I think likewise has bought in to the vision. 00:17:58.786 --> 00:18:01.121 He is a visionary, and he is a hard worker. 00:18:01.121 --> 00:18:03.248 And I want you and Rob Bell, if I 00:18:03.248 --> 00:18:05.918 could keep a clock on who's getting up earlier to work 00:18:05.918 --> 00:18:07.336 on the people's business, it would 00:18:07.336 --> 00:18:09.755 be an interesting competition. 00:18:09.755 --> 00:18:14.051 But this governor knows a good deal when he sees it, 00:18:14.051 --> 00:18:16.303 and he knows a good investment when he sees it. 00:18:16.303 --> 00:18:21.642 And I think he understands that this is, in fact, where 00:18:21.642 --> 00:18:23.894 medicine is going to be in the not too distant future. 00:18:23.894 --> 00:18:26.980 And this governor is obsessed, in a good way, 00:18:26.980 --> 00:18:30.150 with making Virginia competitive with every other state, 00:18:30.150 --> 00:18:32.444 with every other nation. 00:18:32.444 --> 00:18:34.822 And that is no less true in the field of medicine. 00:18:34.822 --> 00:18:36.698 So we're going to build something great here. 00:18:36.698 --> 00:18:39.201 And people are going to come, and we're going to save lives. 00:18:39.201 --> 00:18:41.411 And so with that, His Excellency, Governor Youngkin. 00:18:41.411 --> 00:18:44.873 [APPLAUSE] 00:18:46.792 --> 00:18:47.292 Thank you. 00:18:50.629 --> 00:18:51.296 Thank you. 00:18:54.842 --> 00:18:55.509 Thank you all. 00:18:55.509 --> 00:18:57.219 Good afternoon. 00:18:57.219 --> 00:18:59.471 How much fun is this? 00:18:59.471 --> 00:19:03.767 I understand that we're one of six events happening today. 00:19:03.767 --> 00:19:07.646 So I can't wait to see the next one because this one is 00:19:07.646 --> 00:19:09.314 extraordinary. 00:19:09.314 --> 00:19:13.986 And I just appreciate President Ryan and Rector Clement. 00:19:13.986 --> 00:19:16.280 Thank you for your kind remarks. 00:19:16.280 --> 00:19:18.866 And Mr. Speaker, I have to say that there 00:19:18.866 --> 00:19:21.243 are partnerships that I enjoy. 00:19:21.243 --> 00:19:24.288 The top of the list, of course, is with my amazing wife. 00:19:24.288 --> 00:19:26.707 But I so enjoy working together with you. 00:19:26.707 --> 00:19:27.541 And so, thank you. 00:19:27.541 --> 00:19:29.877 Thank you. 00:19:29.877 --> 00:19:32.963 To Dr. Kent, then all of the teams 00:19:32.963 --> 00:19:38.051 that have worked so tirelessly to bring this idea forward, 00:19:38.051 --> 00:19:41.305 and now to fruition, thank you. 00:19:41.305 --> 00:19:42.181 Thank you. 00:19:42.181 --> 00:19:43.015 Thank you. 00:19:43.015 --> 00:19:46.351 [APPLAUSE] 00:19:48.270 --> 00:19:51.899 I know President Ryan has a theme. 00:19:51.899 --> 00:19:56.153 This theme of pairing together greatness and goodness. 00:19:56.153 --> 00:20:00.574 And it extends beyond this great University. 00:20:00.574 --> 00:20:05.704 And I can't, again, think of a better example, a more salient 00:20:05.704 --> 00:20:10.751 example than the opening of this very institute. 00:20:10.751 --> 00:20:14.171 I'm deeply grateful for all of the work that 00:20:14.171 --> 00:20:16.548 has gone into this. 00:20:16.548 --> 00:20:19.051 But we do need to, again, acknowledge 00:20:19.051 --> 00:20:24.848 that this was an extensive effort from so many people. 00:20:24.848 --> 00:20:27.351 And our colleagues in the General Assembly 00:20:27.351 --> 00:20:33.315 bought in, bought in early, and bought in holistically. 00:20:33.315 --> 00:20:36.401 And the leadership from so many different folks 00:20:36.401 --> 00:20:42.449 reminds us that it does take all of us to get great things done. 00:20:42.449 --> 00:20:46.245 But it takes vision to get started. 00:20:46.245 --> 00:20:48.705 And I want to say thank you. 00:20:48.705 --> 00:20:51.291 Thank you to the Mannings. 00:20:51.291 --> 00:20:54.253 Paul and Diane, I want to thank you for your willingness 00:20:54.253 --> 00:20:56.505 to step forward with more than a vision, 00:20:56.505 --> 00:20:59.174 but a catalytic gift to make it happen. 00:20:59.174 --> 00:21:01.635 And it's when a catalytic gift is 00:21:01.635 --> 00:21:06.139 paired with a vision, a vision to change the future, 00:21:06.139 --> 00:21:09.059 that we will look back at some point in the future 00:21:09.059 --> 00:21:13.105 and say, yes, that day, that day where an announcement was made 00:21:13.105 --> 00:21:16.316 was the beginning of transforming capabilities 00:21:16.316 --> 00:21:20.570 and knowledge that transform lives. 00:21:20.570 --> 00:21:22.990 And so we should all remember this moment 00:21:22.990 --> 00:21:27.786 because that is an exciting time to be in. 00:21:27.786 --> 00:21:33.542 And finally, when all of that comes together, 00:21:33.542 --> 00:21:39.298 and then we execute against it, this tremendous contribution 00:21:39.298 --> 00:21:45.554 will be one that does something more than builds a building 00:21:45.554 --> 00:21:50.517 and provides jobs and advances research. 00:21:50.517 --> 00:21:55.731 But there will be a life, a life that will be saved, 00:21:55.731 --> 00:21:59.026 that could not have been touched or saved 00:21:59.026 --> 00:22:03.113 in any other way than the singularity of the work that 00:22:03.113 --> 00:22:04.906 will be done here. 00:22:04.906 --> 00:22:08.785 And that one life, that one moment 00:22:08.785 --> 00:22:12.664 is the time when we all look back to the vision that 00:22:12.664 --> 00:22:14.541 started with you, and with you. 00:22:14.541 --> 00:22:15.584 And so thank you. 00:22:15.584 --> 00:22:16.376 Thank you. 00:22:16.376 --> 00:22:17.044 Thank you. 00:22:17.044 --> 00:22:20.380 [APPLAUSE] 00:22:24.217 --> 00:22:31.516 I also want to highlight this opportunity for us 00:22:31.516 --> 00:22:36.104 to celebrate the strength of this great university. 00:22:36.104 --> 00:22:42.569 This community has been through a lot in the face of tragedy, 00:22:42.569 --> 00:22:47.908 the horrific shootings of Devin and Lavel 00:22:47.908 --> 00:22:52.079 and D'Sean, three kings, as they were described, 00:22:52.079 --> 00:22:54.414 when we were all together. 00:22:54.414 --> 00:22:57.709 A community that faced that with resilience and strength, 00:22:57.709 --> 00:23:02.255 the community that wrapped your arms together, 00:23:02.255 --> 00:23:06.802 not just intertwined but around one another 00:23:06.802 --> 00:23:11.014 and looked forward to a better day. 00:23:11.014 --> 00:23:17.813 It's a community that represents the best of us all. 00:23:17.813 --> 00:23:21.358 And so today, we have a tremendously happy moment 00:23:21.358 --> 00:23:23.568 to be together. 00:23:23.568 --> 00:23:30.033 And I think that those two days are linked in so many ways 00:23:30.033 --> 00:23:33.662 because it's a community that stands strong 00:23:33.662 --> 00:23:37.624 and it's a community that looks forward. 00:23:37.624 --> 00:23:42.879 This institute that we celebrate today 00:23:42.879 --> 00:23:47.259 will not only be a tremendous asset to UVA, 00:23:47.259 --> 00:23:50.345 to Charlottesville, but its impact 00:23:50.345 --> 00:23:52.347 will stretch across the Commonwealth, 00:23:52.347 --> 00:23:56.476 across the nation, and around the world. 00:23:56.476 --> 00:24:00.105 Virginia, not just the University of, 00:24:00.105 --> 00:24:04.734 but the Commonwealth of will be a leader, 00:24:04.734 --> 00:24:09.239 will be viewed as being the best, the epicenter. 00:24:09.239 --> 00:24:15.328 And we can build on that to not just create jobs 00:24:15.328 --> 00:24:19.458 but to make the Commonwealth a destination. 00:24:19.458 --> 00:24:21.501 A destination for research. 00:24:21.501 --> 00:24:23.837 A destination for care. 00:24:23.837 --> 00:24:27.632 A destination for hope. 00:24:27.632 --> 00:24:29.259 So yes, we'll cut a ribbon today. 00:24:29.259 --> 00:24:30.510 I'm excited about that. 00:24:30.510 --> 00:24:32.471 I like cutting ribbons. 00:24:32.471 --> 00:24:38.852 The ceremonial first step saying that, we're open for business. 00:24:38.852 --> 00:24:41.563 But what comes tomorrow and the day after 00:24:41.563 --> 00:24:44.524 and the day after that is what's so truly exceptional 00:24:44.524 --> 00:24:48.361 because it's the vision of this institute that 00:24:48.361 --> 00:24:51.031 will be fully realized. 00:24:51.031 --> 00:24:56.161 And Virginians will have yet another reason 00:24:56.161 --> 00:24:59.498 to stay within our Commonwealth to receive the best 00:24:59.498 --> 00:25:03.001 possible health care, particularly 00:25:03.001 --> 00:25:05.587 in emerging fields like cellular and gene 00:25:05.587 --> 00:25:11.426 therapy, nanotechnology, and targeted drug delivery. 00:25:11.426 --> 00:25:15.222 These are things that used to be dreams and aspirations that 00:25:15.222 --> 00:25:22.854 will become a reality right here in this amazing hub of research 00:25:22.854 --> 00:25:25.023 and realization. 00:25:25.023 --> 00:25:27.192 I love the word translation. 00:25:27.192 --> 00:25:29.653 As we translate research into reality, 00:25:29.653 --> 00:25:36.868 as we translate visions into fulfilling those aspirations. 00:25:36.868 --> 00:25:39.829 This Institute will do all of that, 00:25:39.829 --> 00:25:43.833 and create hundreds of new jobs here at the University 00:25:43.833 --> 00:25:47.754 of Virginia that generate economic activity, spurning 00:25:47.754 --> 00:25:52.133 companies that will fulfill the translation 00:25:52.133 --> 00:25:56.972 opportunity to deliver all of this great research. 00:25:56.972 --> 00:26:00.267 And beyond that, beyond the research, 00:26:00.267 --> 00:26:02.727 we hope to see manufacturing. 00:26:02.727 --> 00:26:05.605 And we will see capital flow and we 00:26:05.605 --> 00:26:10.193 will see an ecosystem that builds upon itself. 00:26:10.193 --> 00:26:14.781 That is going to be so special to watch. 00:26:14.781 --> 00:26:18.076 One of the most important and most enjoyable 00:26:18.076 --> 00:26:22.914 parts of this privilege that I have every day, as serving all 00:26:22.914 --> 00:26:25.458 of you as your governor, is having the opportunity 00:26:25.458 --> 00:26:30.880 to convince companies and people as to why they should locate 00:26:30.880 --> 00:26:35.260 here in our great Commonwealth, to build their lives, 00:26:35.260 --> 00:26:37.929 to build their children's lives, to expand 00:26:37.929 --> 00:26:42.267 their corporate operations here in Virginia 00:26:42.267 --> 00:26:48.523 because nothing is more rewarding than hearing 00:26:48.523 --> 00:26:52.819 those simple words of, you're hired. 00:26:52.819 --> 00:26:56.573 And I look forward to those words being discussed over 00:26:56.573 --> 00:27:00.285 dinner tables across Virginia, but also 00:27:00.285 --> 00:27:02.078 here more importantly in Charlottesville, 00:27:02.078 --> 00:27:04.039 with this institute. 00:27:04.039 --> 00:27:07.626 But with companies moving here to expand our capacity 00:27:07.626 --> 00:27:10.462 to say those exact words. 00:27:10.462 --> 00:27:12.839 And while each one of the announcements that I 00:27:12.839 --> 00:27:16.801 have the privilege to make is unique and meaningful, 00:27:16.801 --> 00:27:19.763 it's unique and meaningful to communities, 00:27:19.763 --> 00:27:25.018 to the Commonwealth, to the businesses, to their employees, 00:27:25.018 --> 00:27:29.189 there is something very, very, very special about this one. 00:27:29.189 --> 00:27:34.819 It's very special because it is a family stepping forward 00:27:34.819 --> 00:27:40.867 and making a catalytic expression of their belief 00:27:40.867 --> 00:27:43.995 in the success of this institute. 00:27:43.995 --> 00:27:48.792 It's a university bringing every ounce of its capabilities 00:27:48.792 --> 00:27:51.461 to the success of this institute. 00:27:51.461 --> 00:27:54.756 And yes, it's the Commonwealth of Virginia recognizing 00:27:54.756 --> 00:27:58.385 that the part we can play is extraordinarily 00:27:58.385 --> 00:28:00.679 important as well. 00:28:00.679 --> 00:28:05.850 Pairings, greatness and goodness all coming together 00:28:05.850 --> 00:28:10.939 to tackle some of the most challenging, challenging issues 00:28:10.939 --> 00:28:14.609 and questions that face humankind today. 00:28:14.609 --> 00:28:21.366 So you know this inspiration and motivation 00:28:21.366 --> 00:28:26.037 isn't felt for the first time in this amazing building. 00:28:26.037 --> 00:28:27.997 Thomas Jefferson founded this place 00:28:27.997 --> 00:28:31.710 to propel it to become one of the most 00:28:31.710 --> 00:28:35.880 important academic institutes in the world. 00:28:35.880 --> 00:28:39.217 And it's step like this, it's moments 00:28:39.217 --> 00:28:45.098 like this that, I think, allow us to say, yes, Mr. Jefferson. 00:28:45.098 --> 00:28:48.393 We are marching there. 00:28:48.393 --> 00:28:51.563 Folks, it's so fun to be with you. 00:28:51.563 --> 00:28:56.818 It's fun to see Virginia do extraordinary things. 00:28:56.818 --> 00:29:00.363 It's fun to see our capabilities come together 00:29:00.363 --> 00:29:04.200 to take bold steps into the future. 00:29:04.200 --> 00:29:09.581 And as your governor, it's extraordinarily humbling 00:29:09.581 --> 00:29:11.708 to be part of it. 00:29:11.708 --> 00:29:14.210 I'm proud of what we're doing today. 00:29:14.210 --> 00:29:17.547 I'm proud of the efforts that have been brought together. 00:29:17.547 --> 00:29:21.718 And I am so excited to see the great things that 00:29:21.718 --> 00:29:23.428 are yet to come. 00:29:23.428 --> 00:29:24.888 Thank you. 00:29:24.888 --> 00:29:25.764 Thanks to all of you. 00:29:25.764 --> 00:29:27.891 You all have a hand in this. 00:29:27.891 --> 00:29:31.144 But I particularly want to thank the Mannings one last time. 00:29:31.144 --> 00:29:33.480 May God bless you and all that you do. 00:29:33.480 --> 00:29:35.482 Thank you for your hearts. 00:29:35.482 --> 00:29:38.067 Thank you for your vision. 00:29:38.067 --> 00:29:41.404 And on behalf of Virginians and Americans 00:29:41.404 --> 00:29:43.364 and citizens of the world, we thank you 00:29:43.364 --> 00:29:47.118 for what will happen at this most extraordinary institute. 00:29:47.118 --> 00:29:47.952 Thank you very much. 00:29:47.952 --> 00:29:51.206 [APPLAUSE] 00:30:06.721 --> 00:30:10.141 So I'm Craig Kent, CEO of UVA Health. 00:30:10.141 --> 00:30:12.519 And I feel like I drew the short straw 00:30:12.519 --> 00:30:14.229 of having to go after the governor 00:30:14.229 --> 00:30:16.773 and before our honored guest. 00:30:16.773 --> 00:30:18.274 But great to be here. 00:30:18.274 --> 00:30:20.777 And thanks to all of you for being here today. 00:30:20.777 --> 00:30:23.446 And as the governor said, so many of you in this room 00:30:23.446 --> 00:30:26.616 have been instrumental in making this happen. 00:30:26.616 --> 00:30:30.912 I'd like to begin by thanking President Ryan, Rector Clement, 00:30:30.912 --> 00:30:32.997 Board of Visitors, for their vision 00:30:32.997 --> 00:30:36.209 to make UVA preeminent amongst universities 00:30:36.209 --> 00:30:39.963 and academic health systems thanks to an amazing investment 00:30:39.963 --> 00:30:43.091 in translational research and clinical care. 00:30:43.091 --> 00:30:45.760 I would also like to extend my thanks to Governor Youngkin, 00:30:45.760 --> 00:30:48.888 Speaker Gilbert who had the vision and the wisdom 00:30:48.888 --> 00:30:50.849 to support a center for biotechnology 00:30:50.849 --> 00:30:54.394 for the Commonwealth of Virginia that would catalyze innovation 00:30:54.394 --> 00:30:56.938 throughout the state, stimulate collaboration 00:30:56.938 --> 00:31:00.066 amongst the state's major research universities, 00:31:00.066 --> 00:31:03.611 and provide cutting-edge care for Virginia's almost 9 00:31:03.611 --> 00:31:05.822 million citizens. 00:31:05.822 --> 00:31:09.993 Biomedical research is advancing at a pace never before seen. 00:31:09.993 --> 00:31:11.995 It's estimated that the doubling time 00:31:11.995 --> 00:31:14.289 for new knowledge in the field of medicine 00:31:14.289 --> 00:31:16.124 is 2 and 1/2 months. 00:31:16.124 --> 00:31:17.375 So can you imagine that. 00:31:17.375 --> 00:31:19.919 2 and 1/2 months from today, we'll 00:31:19.919 --> 00:31:22.922 twice as much about the medical field as we 00:31:22.922 --> 00:31:24.799 do at this very moment. 00:31:24.799 --> 00:31:27.427 There's so much innovation and new technology. 00:31:27.427 --> 00:31:29.846 And the consequence of this is a greater understanding 00:31:29.846 --> 00:31:32.557 of diseases and potential treatments. 00:31:32.557 --> 00:31:35.143 The beneficiaries of this rapid increase of knowledge 00:31:35.143 --> 00:31:37.729 are our patients, their families, 00:31:37.729 --> 00:31:39.898 and of course, all of the people in the Commonwealth 00:31:39.898 --> 00:31:41.399 of Virginia. 00:31:41.399 --> 00:31:44.611 Over 850,000, or 1 in 10 Virginians, 00:31:44.611 --> 00:31:46.321 suffer from a rare disease. 00:31:46.321 --> 00:31:49.782 Moreover, millions of Virginians suffer from common diseases 00:31:49.782 --> 00:31:52.785 that have no cure, Alzheimer's disease, cancer, 00:31:52.785 --> 00:31:54.120 so many others. 00:31:54.120 --> 00:31:56.164 Many of these are innocent children, 00:31:56.164 --> 00:31:58.791 or the socioeconomically disadvantaged. 00:31:58.791 --> 00:32:01.252 Although advances in medicine in this century 00:32:01.252 --> 00:32:06.007 have been profound, there are still more than 9,500 diseases 00:32:06.007 --> 00:32:08.509 that are without a cure. 00:32:08.509 --> 00:32:11.763 We stand at the cusp of a revolution in health care. 00:32:11.763 --> 00:32:14.223 Biotechnology will change how medicine 00:32:14.223 --> 00:32:17.268 is delivered and the outcomes for our patients, 00:32:17.268 --> 00:32:19.103 not in the distant future, but right 00:32:19.103 --> 00:32:20.813 now and in the coming years. 00:32:20.813 --> 00:32:23.358 We already see it happening. 00:32:23.358 --> 00:32:27.278 The annual economic impact for the US bioscience industry 00:32:27.278 --> 00:32:30.239 is $2.9 trillion. 00:32:30.239 --> 00:32:32.867 This is only superseded by the size of the health care 00:32:32.867 --> 00:32:36.454 industry, which is annually $4.3 trillion. 00:32:36.454 --> 00:32:38.498 Both biotech and health care continue 00:32:38.498 --> 00:32:41.793 to grow at an exponential rate. 00:32:41.793 --> 00:32:44.921 With our new biotech unit, Virginia 00:32:44.921 --> 00:32:47.382 is positioning itself to be a benefactor 00:32:47.382 --> 00:32:49.467 of that incredible growth. 00:32:49.467 --> 00:32:51.302 While the economics are important, 00:32:51.302 --> 00:32:55.431 the most exciting impact of this biotechnology revolution, 00:32:55.431 --> 00:32:58.226 from my perspective as a health care provider and a health care 00:32:58.226 --> 00:33:00.812 leader, is how biotechnology will 00:33:00.812 --> 00:33:03.940 save lives and improve the quality of life 00:33:03.940 --> 00:33:05.066 of our patients. 00:33:05.066 --> 00:33:08.486 With increased investment in the pursuit of new innovations, 00:33:08.486 --> 00:33:11.030 imagine how incredible the future will be 00:33:11.030 --> 00:33:12.949 for the citizens of Virginia. 00:33:12.949 --> 00:33:16.703 And this will all be happening right here on grounds 00:33:16.703 --> 00:33:19.372 at the University of Virginia. 00:33:19.372 --> 00:33:21.416 Universities and academic medical centers 00:33:21.416 --> 00:33:24.502 across the country are playing an increasingly important role 00:33:24.502 --> 00:33:26.254 in translational therapeutics. 00:33:26.254 --> 00:33:28.131 The Paul and Diane Manning Institute 00:33:28.131 --> 00:33:30.800 will be designed to fill the gap between the research 00:33:30.800 --> 00:33:33.845 bench and the hospital bedside by focusing 00:33:33.845 --> 00:33:37.932 on the rapid development of innovative medical therapies. 00:33:37.932 --> 00:33:40.351 What will be accomplished at this institute? 00:33:40.351 --> 00:33:44.480 The recruitment of over 100 new physicians and scientists 00:33:44.480 --> 00:33:46.482 focused on translational research. 00:33:46.482 --> 00:33:49.277 These researchers will bring to the Commonwealth annually 00:33:49.277 --> 00:33:53.156 up to $150 million of externally funded research, 00:33:53.156 --> 00:33:57.201 enhancing the Commonwealth's economics and reputation. 00:33:57.201 --> 00:33:59.996 The creation of a life sciences ecosystem 00:33:59.996 --> 00:34:03.750 that will attract world class talent and the influx of health 00:34:03.750 --> 00:34:05.793 care and biotech companies. 00:34:05.793 --> 00:34:07.503 We will accelerate the development 00:34:07.503 --> 00:34:10.840 of innovative, revolutionary new clinical therapies, including 00:34:10.840 --> 00:34:14.552 cellular and gene therapies, nanotechnology, targeted drug 00:34:14.552 --> 00:34:17.722 delivery, positioning UVA and Virginia 00:34:17.722 --> 00:34:20.808 to be at the forefront of cutting-edge next generation 00:34:20.808 --> 00:34:21.642 medicine. 00:34:21.642 --> 00:34:24.729 And most importantly, very most importantly, 00:34:24.729 --> 00:34:27.648 the promise that Virginians will no longer need to leave 00:34:27.648 --> 00:34:30.234 the Commonwealth to receive world class, 00:34:30.234 --> 00:34:32.820 state-of-the-art clinical care. 00:34:32.820 --> 00:34:35.031 There's no better way to demonstrate what the Manning 00:34:35.031 --> 00:34:38.159 biotechnology Institute will bring to Virginia than to tell 00:34:38.159 --> 00:34:39.994 two patient stories. 00:34:39.994 --> 00:34:43.372 I'd like to first introduce you to Colin He's nine years old. 00:34:43.372 --> 00:34:48.294 He was diagnosed with acute lymphoblastic leukemia in 2018. 00:34:48.294 --> 00:34:50.213 Colin presented to his pediatricians 00:34:50.213 --> 00:34:51.506 with generalized pain. 00:34:51.506 --> 00:34:54.801 And after an evaluation by UVA Health pediatricians, 00:34:54.801 --> 00:34:57.720 his parents received a phone call that everyone fears, 00:34:57.720 --> 00:34:59.639 Colin has cancer. 00:34:59.639 --> 00:35:01.349 The standard treatment for leukemia 00:35:01.349 --> 00:35:04.936 is induction chemotherapy, which is highly toxic. 00:35:04.936 --> 00:35:08.314 Colin's chemotherapy produced severe complications, 00:35:08.314 --> 00:35:11.275 including pancreatitis, the need for a ventilator, 00:35:11.275 --> 00:35:13.111 the need for a feeding tube. 00:35:13.111 --> 00:35:15.196 This was devastating to Colin, of course, 00:35:15.196 --> 00:35:16.864 but also for his family. 00:35:16.864 --> 00:35:19.283 But with treatment, Colin's cancer 00:35:19.283 --> 00:35:23.538 went into remission but the relief did not last long. 00:35:23.538 --> 00:35:26.958 Within a few months, the cancer was back. 00:35:26.958 --> 00:35:29.210 UVA Health was then able to offer Colin 00:35:29.210 --> 00:35:32.463 a cutting-edge treatment for childhood leukemia 00:35:32.463 --> 00:35:34.298 that was only recently developed. 00:35:34.298 --> 00:35:37.885 The treatment is called chimeric antigen receptor, or CAR T cell 00:35:37.885 --> 00:35:39.512 therapy. 00:35:39.512 --> 00:35:40.888 This is how it works. 00:35:40.888 --> 00:35:42.849 We remove a patient's immune cells, 00:35:42.849 --> 00:35:46.519 and then modify these cells in a special laboratory called a GMP 00:35:46.519 --> 00:35:47.478 facility. 00:35:47.478 --> 00:35:50.398 UVA is amongst an elite group of institutions 00:35:50.398 --> 00:35:53.234 nationwide with a GMP program. 00:35:53.234 --> 00:35:55.820 Outside the patient's body and in this facility, 00:35:55.820 --> 00:35:58.906 cells are taught to selectively target and kill 00:35:58.906 --> 00:36:01.242 the patient's own cancer cells. 00:36:01.242 --> 00:36:07.206 These trained killer cells were then infused back into Colin. 00:36:07.206 --> 00:36:09.292 We held our breath and waited. 00:36:09.292 --> 00:36:12.753 Within a month, the cancer had completely disappeared. 00:36:12.753 --> 00:36:15.214 And two years later, to this day, 00:36:15.214 --> 00:36:18.384 Colin remains in remission Colin is now 00:36:18.384 --> 00:36:21.429 an active fun-loving child with no sign of leukemia, 00:36:21.429 --> 00:36:25.391 thanks to Dr. Trey Lee, the pediatric oncology team at UVA, 00:36:25.391 --> 00:36:27.435 and most importantly, the advances 00:36:27.435 --> 00:36:31.230 that we've spoken about today many times in medical science. 00:36:31.230 --> 00:36:33.232 I would next like to introduce you to Isabel. 00:36:33.232 --> 00:36:37.486 Spinal Muscular Atrophy, or SMA, is a disease of young children. 00:36:37.486 --> 00:36:39.614 It's produced by a mutation in a gene that 00:36:39.614 --> 00:36:42.825 manufactures a protein that's necessary for muscles 00:36:42.825 --> 00:36:43.868 to mature. 00:36:43.868 --> 00:36:45.703 For those who are born with this mutation, 00:36:45.703 --> 00:36:47.455 muscles atrophy become weak. 00:36:47.455 --> 00:36:49.540 And the majority of children who have the syndrome 00:36:49.540 --> 00:36:51.876 don't survive beyond the age of two. 00:36:51.876 --> 00:36:54.462 During my tenure as Dean of the School of Medicine at the Ohio 00:36:54.462 --> 00:36:56.756 State University and Nationwide Children's Hospital, 00:36:56.756 --> 00:36:59.175 a novel gene therapy was developed there, 00:36:59.175 --> 00:37:02.595 which replaces the abnormal non-functioning gene 00:37:02.595 --> 00:37:05.014 in patients with SMS. 00:37:05.014 --> 00:37:06.682 Animal studies were encouraging. 00:37:06.682 --> 00:37:10.686 And with the backing of an investor, whose name you 00:37:10.686 --> 00:37:13.314 will recognize, Paul Manning. 00:37:13.314 --> 00:37:15.858 Yes, our paths did cross in a previous life. 00:37:15.858 --> 00:37:18.945 This technology moved quickly into clinical trials. 00:37:18.945 --> 00:37:20.738 Fast forward to Isabel, a patient 00:37:20.738 --> 00:37:24.992 at UVA Children's Hospital born in January of 2019. 00:37:24.992 --> 00:37:26.744 Her family and pediatricians found 00:37:26.744 --> 00:37:28.329 that she had difficulty with movement, 00:37:28.329 --> 00:37:29.622 and she was not thriving. 00:37:29.622 --> 00:37:32.625 And the diagnosis of SMA was made. 00:37:32.625 --> 00:37:35.836 After an infusion of the SMA gene therapy, which 00:37:35.836 --> 00:37:38.297 replaced the absent protein, Isabel 00:37:38.297 --> 00:37:40.508 showed dramatic improvement and is now 00:37:40.508 --> 00:37:42.385 living a functional life. 00:37:42.385 --> 00:37:44.679 Before the therapy, she was not able to stand. 00:37:44.679 --> 00:37:47.598 But she is now an active child chased around the house 00:37:47.598 --> 00:37:48.683 by her parents. 00:37:48.683 --> 00:37:51.519 Another miracle at the UVA Children's Hospital. 00:37:51.519 --> 00:37:54.230 The result of the advancements of medical science 00:37:54.230 --> 00:37:56.565 and technology. 00:37:56.565 --> 00:37:58.317 President Ryan already introduced 00:37:58.317 --> 00:38:01.362 our generous benefactors, Paul and Diane Manning. 00:38:01.362 --> 00:38:04.573 While philanthropic gifts are commonplace at a nationally 00:38:04.573 --> 00:38:06.867 acclaimed university as beloved and as prestigious 00:38:06.867 --> 00:38:11.247 as the University of Virginia, the $100 million 00:38:11.247 --> 00:38:14.166 gift contributed by Paul and Diane 00:38:14.166 --> 00:38:18.087 has exceeded any of our wildest hopes and dreams. 00:38:18.087 --> 00:38:24.093 In fact, one of Paul's frequent sayings is, go big or go home. 00:38:24.093 --> 00:38:27.179 Although he uses these words when referring endearingly 00:38:27.179 --> 00:38:28.723 to our new biotechnical institute, 00:38:28.723 --> 00:38:31.350 and I'm so excited about that, his contribution 00:38:31.350 --> 00:38:35.563 of $100 million has lived up to that adage as well. 00:38:35.563 --> 00:38:38.149 What differentiates Paul from other donors? 00:38:38.149 --> 00:38:40.818 It turns out he is one of the world's experts 00:38:40.818 --> 00:38:43.362 in what we are all about to create. 00:38:43.362 --> 00:38:45.990 Not only is he contributing his resources, 00:38:45.990 --> 00:38:48.743 but we also have the benefit of his expertise 00:38:48.743 --> 00:38:52.621 and worldwide connections in the biotechnical field. 00:38:52.621 --> 00:38:54.582 Although I've been a physician and a researcher 00:38:54.582 --> 00:38:58.294 for the past 30 years, on most days, although I try, 00:38:58.294 --> 00:39:01.505 I can't keep up with Paul, his energy, his innovation, 00:39:01.505 --> 00:39:03.049 and his ingenuity. 00:39:03.049 --> 00:39:05.217 It has been wonderful over the past year and a half 00:39:05.217 --> 00:39:09.638 to become Paul's friend and a partner in this initiative. 00:39:09.638 --> 00:39:14.810 With Paul as our supporter, I am confident that we, at UVA, 00:39:14.810 --> 00:39:16.854 and the Commonwealth of Virginia will soon 00:39:16.854 --> 00:39:22.360 have one of the top biotechnical institutes in the country. 00:39:22.360 --> 00:39:26.322 Paul and Diane, I am so thankful for your vision, 00:39:26.322 --> 00:39:29.533 devotion, compassion, and enthusiasm. 00:39:29.533 --> 00:39:32.828 Please everyone extend an incredibly warm 00:39:32.828 --> 00:39:34.705 welcome to Paul and Diane Manning. 00:39:34.705 --> 00:39:38.000 [APPLAUSE] 00:39:52.932 --> 00:39:58.020 So I have this actually a very short speech 00:39:58.020 --> 00:40:01.107 compared to these guys. 00:40:01.107 --> 00:40:05.403 But they've already said everything that's in this. 00:40:05.403 --> 00:40:11.409 And I may read it because I put like 25 minutes into it. 00:40:11.409 --> 00:40:17.289 So yesterday was my anniversary of 38 years to Diane. 00:40:17.289 --> 00:40:19.417 [APPLAUSE] 00:40:19.417 --> 00:40:22.086 And there's no better way to celebrate. 00:40:22.086 --> 00:40:24.797 She's been such a great partner for me. 00:40:24.797 --> 00:40:26.257 And I wouldn't be here without her. 00:40:26.257 --> 00:40:30.010 So just, for that, This isn't in the speech. 00:40:30.010 --> 00:40:31.887 But I figured since you guys said everything, 00:40:31.887 --> 00:40:33.013 I'd say a few other things. 00:40:33.013 --> 00:40:38.602 So Bryan and Court, my son and daughter-in-law had their son 00:40:38.602 --> 00:40:41.313 saved here a year ago at UVA from the doctors 00:40:41.313 --> 00:40:43.107 in cardiac medicine. 00:40:43.107 --> 00:40:47.319 He had a real serious cardiac problem. 00:40:47.319 --> 00:40:49.196 And they did surgery underneath his arm. 00:40:49.196 --> 00:40:53.033 And they went in there, and they replaced one of the veins, 00:40:53.033 --> 00:40:55.661 and, how do I put it, an artery. 00:40:55.661 --> 00:40:57.913 Thanks. 00:40:57.913 --> 00:40:59.498 And he was saved. 00:40:59.498 --> 00:41:02.084 And that's a fantastic thing. 00:41:02.084 --> 00:41:03.919 That's a really fantastic thing that we 00:41:03.919 --> 00:41:06.505 were able to see that happen here at the university. 00:41:06.505 --> 00:41:08.716 And that's why we're lucky to be here. 00:41:08.716 --> 00:41:12.303 The thing that Craig was talking about was AveXis. 00:41:12.303 --> 00:41:14.680 As a company, we went in five years ago. 00:41:14.680 --> 00:41:19.727 And I saw this gentleman by the name of Brian Kaspar. 00:41:19.727 --> 00:41:21.353 Brian Kaspar was a doctor there. 00:41:21.353 --> 00:41:23.355 And he couldn't raise any money for gene therapy 00:41:23.355 --> 00:41:26.984 because the Gelsinger child up in Pennsylvania, 00:41:26.984 --> 00:41:30.738 Dr. Wilson treated him and he died because they 00:41:30.738 --> 00:41:34.617 used a virus that the child has seen before, 00:41:34.617 --> 00:41:35.910 and he had immune response. 00:41:35.910 --> 00:41:38.037 And so nobody wanted to do gene therapy. 00:41:38.037 --> 00:41:41.749 And so I went there and saw Brian Kaspar and Sean Stalfort, 00:41:41.749 --> 00:41:44.710 who's been fantastic for us. 00:41:44.710 --> 00:41:47.338 Helped me get there to see this guy in Nationwide Children, 00:41:47.338 --> 00:41:48.714 where Craig worked. 00:41:48.714 --> 00:41:51.425 And I went for probably 40 minutes, right, Sean? 00:41:51.425 --> 00:41:53.928 We went in and saw this video of these pigs walking up 00:41:53.928 --> 00:41:54.428 this ramp. 00:41:54.428 --> 00:41:56.013 The ones on the right had been treated 00:41:56.013 --> 00:41:58.349 and the ones on the left had not been treated. 00:41:58.349 --> 00:42:02.228 And the ones on the right were falling off the ramp, 00:42:02.228 --> 00:42:04.188 and the ones on the left with this gene therapy 00:42:04.188 --> 00:42:05.314 were walking up the ramp. 00:42:05.314 --> 00:42:08.108 And Brian Kaspar said, I don't have any money. 00:42:08.108 --> 00:42:09.944 He says, I'm going to go out of business. 00:42:09.944 --> 00:42:11.904 Gene therapy is going to fail in America. 00:42:11.904 --> 00:42:15.157 Would you give me $5 million for a $20 million 00:42:15.157 --> 00:42:18.118 valuation in this company? 00:42:18.118 --> 00:42:20.538 And I walked them over to the side room. 00:42:20.538 --> 00:42:23.582 And I said, Brian, is this made up stuff 00:42:23.582 --> 00:42:24.667 on the video or something? 00:42:24.667 --> 00:42:26.293 These pigs were trained on the left? 00:42:26.293 --> 00:42:27.127 And he said, no, no. 00:42:27.127 --> 00:42:30.839 This is this is absolutely true. 00:42:30.839 --> 00:42:32.633 So I walked out of that conference room 00:42:32.633 --> 00:42:35.010 and I told Sean, we're going to give this guy $5 million. 00:42:35.010 --> 00:42:36.428 He says, any more due diligence? 00:42:36.428 --> 00:42:37.054 I said, no. 00:42:37.054 --> 00:42:41.392 Because if these 1,200 kids a year are going to die, 00:42:41.392 --> 00:42:44.311 then it's philanthropic or it's commercial. 00:42:44.311 --> 00:42:47.898 But one of the ways, we're going to get these kids a chance. 00:42:47.898 --> 00:42:52.027 And long story short, we sat closely by the phone 00:42:52.027 --> 00:42:53.404 when the first baby was injected. 00:42:53.404 --> 00:42:55.489 No immune response. 00:42:55.489 --> 00:43:00.077 And then three days later, no immune response. 00:43:00.077 --> 00:43:01.954 Two weeks later, three weeks later, 00:43:01.954 --> 00:43:04.832 Dr. Mendel calls us and says, by the way, 00:43:04.832 --> 00:43:07.668 I don't know but it looks like this baby is starting to move. 00:43:07.668 --> 00:43:10.713 And this baby had 12 months to live. 00:43:10.713 --> 00:43:13.048 Long story shorter, three months later, the baby 00:43:13.048 --> 00:43:16.677 starts doing natural stuff, doing its own walking around 00:43:16.677 --> 00:43:19.847 like a normal kid, crawling around like a normal kid. 00:43:19.847 --> 00:43:22.766 Five years later, the kid's in first grade running around 00:43:22.766 --> 00:43:23.809 with the other kids. 00:43:23.809 --> 00:43:25.769 Now, 1,200 kids get treated a year 00:43:25.769 --> 00:43:27.646 in America that gets saved. 00:43:27.646 --> 00:43:30.482 Over 3,000 kids a year around the world get treated. 00:43:30.482 --> 00:43:34.403 And it's only because of cellular medicine cell therapy, 00:43:34.403 --> 00:43:36.864 what he was talking about, that these kids get saved. 00:43:36.864 --> 00:43:40.701 And it's so important that we do this here in Virginia 00:43:40.701 --> 00:43:45.080 because we have the chance to change lives, dramatically 00:43:45.080 --> 00:43:46.915 change lives. 00:43:46.915 --> 00:43:50.377 For Alzheimer's, ALS, sickle cell, blindness, hearing, 00:43:50.377 --> 00:43:52.254 we're going to change those lives here. 00:43:52.254 --> 00:43:54.590 And we're going to have patients coming here 00:43:54.590 --> 00:43:55.924 from Virginia for sure. 00:43:55.924 --> 00:43:58.344 And one of the things I said is a patient in Virginia 00:43:58.344 --> 00:44:00.804 that may not have the wherewithal 00:44:00.804 --> 00:44:02.389 to be able to go to the Mayo, M.D. 00:44:02.389 --> 00:44:06.268 Anderson, Hopkins, Duke, Boston, those people are going 00:44:06.268 --> 00:44:08.062 to get in their cars and drive to here 00:44:08.062 --> 00:44:10.022 and get the treatments that they would get there that wouldn't 00:44:10.022 --> 00:44:10.898 get these treatments. 00:44:10.898 --> 00:44:12.483 And these kids with sickle cell anemia 00:44:12.483 --> 00:44:15.027 now can get gene therapy, that they wouldn't get normally. 00:44:15.027 --> 00:44:18.155 And they can live now by getting treated at Charlottesville. 00:44:18.155 --> 00:44:22.034 So that's an important thing because now, it's not available 00:44:22.034 --> 00:44:22.576 here. 00:44:22.576 --> 00:44:24.662 And it will be available here. 00:44:24.662 --> 00:44:26.664 So I have a lot more to say. 00:44:26.664 --> 00:44:28.499 It's trillion dollar industry. 00:44:28.499 --> 00:44:30.084 We're going to bring companies here. 00:44:30.084 --> 00:44:31.752 We're going to have them set up here. 00:44:31.752 --> 00:44:33.545 We're going to have them partner with the university. 00:44:33.545 --> 00:44:34.797 We're going to have them invest in manufacturing. 00:44:34.797 --> 00:44:37.132 We're going to invest in the science. 00:44:37.132 --> 00:44:40.761 And we are going to explode because who 00:44:40.761 --> 00:44:42.846 wants to be in Boston when you can be in Virginia? 00:44:42.846 --> 00:44:44.181 Yeah, totally. 00:44:44.181 --> 00:44:47.518 [LAUGHS] 00:44:49.436 --> 00:44:54.942 Anyways, listen, you can't do this without these two. 00:44:54.942 --> 00:44:58.654 I mean, Jim Ryan could actually now be a medical salesperson. 00:44:58.654 --> 00:45:00.239 He's learned so much about this stuff. 00:45:00.239 --> 00:45:03.325 He wants to quit, he could sell biotech equipment or anything. 00:45:03.325 --> 00:45:05.327 I've never seen anybody learn so much. 00:45:05.327 --> 00:45:07.413 That's why I can't give this speech because he 00:45:07.413 --> 00:45:09.289 knows too much already. 00:45:09.289 --> 00:45:10.499 But thanks to the speaker. 00:45:10.499 --> 00:45:11.458 Thanks to Whitt. 00:45:11.458 --> 00:45:12.334 Thanks to Jim. 00:45:12.334 --> 00:45:13.460 Thanks for the governor. 00:45:13.460 --> 00:45:14.545 Thanks to Mark. 00:45:14.545 --> 00:45:16.088 Thanks for all of you guys. 00:45:16.088 --> 00:45:19.800 I appreciate Don Mosman's help, all the PBM team that gave me 00:45:19.800 --> 00:45:22.428 the opportunity to get here. 00:45:22.428 --> 00:45:24.596 Karen Rendleman, Mark Luellen and all the people 00:45:24.596 --> 00:45:27.725 that, over the years, got us to invest in the university, 00:45:27.725 --> 00:45:29.435 we've been doing it for 15 years, 00:45:29.435 --> 00:45:31.854 got us to invest, give money, be happy. 00:45:31.854 --> 00:45:32.896 They execute well. 00:45:32.896 --> 00:45:34.106 They hit their milestones. 00:45:34.106 --> 00:45:35.399 They know what they're doing. 00:45:35.399 --> 00:45:38.318 This is going to be the most successful biotech institute 00:45:38.318 --> 00:45:40.028 in the country, maybe the world. 00:45:40.028 --> 00:45:41.780 And we are going to drive forward. 00:45:41.780 --> 00:45:44.158 And we're all going to be thrilled that we're part of it. 00:45:44.158 --> 00:45:46.660 So I can't thank everybody enough. 00:45:46.660 --> 00:45:47.411 I didn't read it. 00:45:47.411 --> 00:45:50.873 [APPLAUSE] 00:46:19.693 --> 00:46:21.612 I don't know about you, but I to grab a shovel 00:46:21.612 --> 00:46:24.698 and go start digging and get this thing started right now. 00:46:24.698 --> 00:46:26.825 So thanks again to all of you for being here. 00:46:26.825 --> 00:46:29.953 Thanks to everyone who has helped us get to this point. 00:46:29.953 --> 00:46:32.080 Mr. Governor, Mr. Speaker, thank you 00:46:32.080 --> 00:46:35.751 for honoring us by being here with us today. 00:46:35.751 --> 00:46:39.338 And one last thanks to the two who made this happen, Paul 00:46:39.338 --> 00:46:40.088 and Diane Manning. 00:46:40.088 --> 00:46:40.964 Thank you so much. 00:46:40.964 --> 00:46:44.301 [APPLAUSE]